熊本大学大学院生命科学研究部 分子遺伝学分野

業績

○過去の業績はこちら

2018年業績

(*Corresponding author)

  1. Itoh H#, Kadomatsu T#, Tanoue H, Yugami M, Miyata K, Endo M, Morinaga J, Kobayashi E, Miyamoto T, Kurahashi R, Terada K, Mizuta H & Oike Y*. (# equally contributed)
    TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma.
    Oncogene 37:2903-2920, 2018
  2. Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H & Oike Y*.
    Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
    Osteoarthritis Cartilage 26:108-117, 2018
  3. Zhao J#, Tian Z#, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K & Oike Y*. (# equally contributed)
    Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
    J Biol Chem 293:1596-1609, 2018
  4. Tian Z, Miyata K, Morinaga J, Horiguchi H, Kadomatsu T, Endo M, Zhao J, Zhu S, Sugizaki T, Sato M, Terada K, Okumura T, Murohara T & Oike Y*.
    Circulating ANGPTL2 levels increase in humans and mice exhibiting cardiac dysfunction.
    Circ J 82:437-447, 2018
  5. Morinaga J#, Zhao J#, Endo M#, Kadomatsu T, Miyata K, Sugizaki T, Okadome Y, Tian Z, Horiguchi H, Miyashita K, Maruyama N, Mukoyama M & Oike Y*. (#equally contributed)
    Association of circulating ANGPTL 3, 4, anf 8 levels with medical status in a population undergoing routine medical checkups: a cross-sectional study.
    PLoS One 13:e0193731, 2018
  6. Ishii T, Furuya F, Takahashi K, Shikata M, Takamura T, Kobayashi H, Miyazaki A, Morinaga J, Terada K, Oike Y, Kanda E & Kitamura K.
    Angiopoietin-like protein 2 promotes the progression of diabetic kidney disease.
    J Clin Endocrinol Metab 2018 in press
  7. Nugroho DB, Ikeda K, Barinda AJ, Wardhana DA, Yagi K, Miyata K, Oike Y, Hirata KI & Emoto N.
    Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature.
    Biochem Biophys Res Commun 503:378-384, 2018
  8. Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H & Yamagata K.
    SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
    Nat Commun 9:2833, 2018
  9. Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, Ohkawa Y, Miyata K, Oike Y, Shirane M, Nishiyama M & Nakayama KI.
    The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis.
    Cell Rep 23:1988-2000, 2018
  10. Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R & Kanai T.
    Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis.
    J Clin Invest 128:1581-1596, 2018
  11. Wardhana D, Ikeda K, Barinda A, Nugroho D, Qurania K, Yagi K, Miyata K, Oike Y, Hirata K & Emoto N.
    Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis.
    Proc Natl Acad Sci USA 115:1529-1534, 2018
  12. Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T & Tomizawa K.
    Defective mitochondrial tRNA taurine modification activates global proteostress and leads to mitochondrial disease.
    Cell Rep 22:482-496, 2018
  13. Korogi W, Yoshizawa T, Karim F, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H & Yamagata K.
    SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
    Biochem Biophys Res Commun 496:891-897, 2018

2017年業績

(*Corresponding author)

  1. Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K & Oike Y*.
    ANGPTL2 expression in intestinal stem cell niche controls epithelial regeneration and homeostasis.
    EMBO J 36:409-424, 2017
    Selected for cover page
  2. Sugizaki T#, Zhu S#, Guo G, Matsumoto A, Zhao J, Endo M, Horiguchi H, Morinaga J, Tian Z, Kadomatsu T, Miyata K, Itoh H & Oike Y*. (# equally contributed)
    Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality.
    NPJ Aging Mech Dis 3:12, 2017
  3. Oike Y*, Tian Z, Miyata K, Morinaga J, Endo M & Kadomatsu T.
    ANGPTL2: a new causal player in accelerating heart disease development in the aging.
    Circ J 81:1379-1385, 2017
  4. Kusumoto Y, Irie J, Iwabu K, Tagawa H, Itoh A, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Yamada S, Kawai T, Watanabe M, Oike Y & Itoh H.
    Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice.
    Metabolism 71:1-6, 2017
  5. Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y & Shong M.
    ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.
    J Endocrinol 233:105-118, 2017
  6. Ahmed KA, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T & Sawa T.
    Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic
    Monophosphorothioate Rp-isomer as a Potent Inhibitor of Protein Kinase G1α.

    Biol Pharm Bull 40:365-374, 2017

2016年業績

(*Corresponding author)

  1. Tian Z#, Miyata K#, Kadomatsu T#, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M & Oike Y*. (# equally contributed)
    ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.
    Nat Commun 7:13016, 2016
  2. Morinaga J, Kadomatsu T, Miyata K, Endo M, Terada K, Tian Z, Sugizaki T, Tanigawa H, Zhao J, Zhu S, Sato M, Araki K, Iyama K, Tomita K, Mukoyama M,Tomita K, Kitamura K & Oike Y*.
    ANGPTL2 increases renal fibrosis by accelerating TGF-β signaling in chronic kidney disease.
    Kidney Int  89:327-341, 2016
    Selected for cover page
  3. Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H & Oike Y*.
    Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
    Sci Rep 6:34690, 2016
  4. Motokawa I, Endo M, Terada K, Horiguchi H, Miyata K, Kadomatsu T, Morinaga J, Sugizaki T, Ito T, Araki K, Morioka MS, Manabe I, Samukawa T, Watanabe M, Inoue H & Oike Y.
    Interstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.
    Am J Physiol Lung Cell Mol Physiol 311:L704-L713, 2016
  5. Yugami M#, Odagiri H#, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H & Oike Y*. (# equally contributed)
    Mice deficient in Angptl2 show increased susceptibility to bacterial infection due to attenuated macrophage activity.
    J Biol Chem 291:18843-18852, 2016
  6. Amadatsu T, Morinaga J, Kawano T, Terada K,Kadomatsu T, Miyata K, Endo M, Kasamo D, Kuratsu JI & Oike Y*.
    Macrophage-derived angiopoietin-like protein 2 exacerbates brain damage by accelerating acute inflammation after ischemia-reperfusion.
    PLoS One 11:e0166285, 2016
  7. Wu Y, Wei F-Y, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, KaitsukaT, Takeya M, Oike Y, Suzuki T & Tomizawa K.
    Mtu1-mediated thiouridine formation of mitochondrial tRNAs is required for mitochondrial translation and is involved in reversible infantile liver injury.
    PLoS Genet 12: e1006355, 2016
  8. Ogata F, Fujiu K, Matsumoto S, Nakayama Y, Shibata M, Oike Y, Koshima I, Watabe T, Nagai R & Manabe I.
    Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema.
    J Invest Dermatol 136:706-714, 2016
  9. Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y & Ninomiya T.
    Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study.
    Arterioscler Thromb Vasc Biol 36:1686-1691, 2016
  10. Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y & Ozawa Y.
    Angiopoietin-like protein 2 is a multiple regulator of inflammatory neovascularization in a murine model of age-related macular degeneration.
    J Biol Chem 291:7373-7385,2016
  11. Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S & Akaike T.
    Persistent activation of cGMP-dependent protein kinase by a nitrated cyclic nucleotide via site-specific protein S-guanylation.
    Biochemistry 55:751-761, 2016

2015年業績

(*Corresponding author)

  1. Oike Y*
    Cutting-edge research exploring mechanisms of tissue homeostasis in health and disease.
    Inflamm Regen 35:164-166, 2015
  2. Oike Y*, Kadomatsu T & Endo M.
    The role of ANGPTL2-induced chronic inflammation in lifestyle diseases and cancer.
    Inflamm Regen 35:193-202, 2015
  3. Masuda T, Endo M, Yamamoto Y, Odagiri H, Kadomatsu T, Nakamura T, Tanoue H, Ito H, Yugami M, Miyata K, Morinaga J, Horiguchi H, Motokawa I, Terada K, Morioka MS, Manabe I, Iwase H, Mizuta H & Oike Y*.
    ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.
    Sci Rep 5:9170, 2015
  4. Nakamura T, Okada T, Endo M, Nakamura T, Oike Y & Mizuta H.
    Angiopoietin-like protein 2 promotes inflammatory conditions in the ligamentum flavum in the pathogenesis of lumbar spinal canal stenosis by activating interleukin-6 expression.
    Eur Spine J 24:2001-2009, 2015
  5. Wei FY, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y & Tomizawa K.
    Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs precise mitochondrial protein translation and contributes to myopathy in mice and humans.
    Cell Metab 21:428-442, 2015
  6. Shimizu N, Maruyama T, Toshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H.
    A muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling.
    Nat Commun 6:6693, 2015
  7. Tanaka Y, Ishitsuka Y, Hayasaka M, Yamada Y, Miyata K, Endo M, Kondo Y, Moriuchi H, Irikura M, Tanaka KI, Mizushima T, Oike Y & Irie T.
    The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice.
    Pharmacol Res 99:52-62, 2015
  8. Niwa M, Numaguchi Y, Ishii M, Kuwahata T, Kondo M, Shibata R, Miyata K, Oike Y & Murohara T.
    IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.
    Biochem Biophys Res Commun 457:12-18, 2015

2014年業績

(*Corresponding author)

  1. Odagiri H#, Kadomatsu T#, Endo M, Masuda T, Morioka MS, Fukuhara S, Miyamoto T, Kobayashi E,Miyata K, Aoi J, Horiguchi H, Nishimura N, Terada K, Yakushiji T, Manabe I, Mochizuki N, Mizuta H & Oike Y*.(# equally contributed)
    The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.
    Sci Signal 7:ra7, 2014
    Science Signaling Podcast: 21 January 2014
    http://stke.sciencemag.org/cgi/content/full/7/309/pc3/DC1
  2. Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K & Oike Y*.
    Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.
    Arterioscler Thromb Vasc Biol 34:790-800, 2014
    Selected for cover page
  3. Endo M, Yamamoto Y, Nakano M, Masuda T, Odagiri H,  Horiguchi H, Miyata K, Kadomatsu T, Motokawa I, Okada S, Iwase H & Oike Y.
    Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis.
    Int J Biol Markers 29:e239-245, 2014
  4. Kadomatsu T, Endo M, Miyata K & Oike Y*.
    Diverse roles of ANGPTL2 in physiology and pathophysiology.
    Trends Endocrinol Metab 25:245-254, 2014
  5. Horiguchi H, Endo M, Miyamoto Y, Sakamoto Y, Odagiri H, Masuda T, Kadomatsu T, Tanoue H, Motokawa I, Terada K, Morioka MS, Manabe I, Baba H & Oike Y*.
    ANGPTL2 renders colorectal cancer cells resistant to chemotherapy bu activating Syk-PI3K-dependent anti-apoptotic signaling.
    Cancer Sci 105:1550-1559, 2014
  6. Nakamura T, Okada T, Endo M, Kadomatsu T, Taniwaki T, Sei A, Odagiri H, Masuda T, Fujimoto T, Nakamura T, Oike Y & Mizuta H.
    Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.
    PLoS One 9:e85542, 2014
  7. Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H & Oike Y*.
    Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress.
    Mol Cancer Res 12:239-249, 2014
  8. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E & Yamagata K.
    SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
    Cell Metab 19:712-721, 2014
  9. Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb M-H & Murakami M.
    The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
    Cell Metab 20:119-132, 2014
  10. Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y & Irie T.
    Protection afforded by pre- or post-treatment with 4-Phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
    Pharmacol Res 87:26-41, 2014
  11. Swain L, Wottawa M, Hillemann A, Beneke A, Odagiri H, Terada K, Endo M, Oike Y, Farhat K & Katschinski DM.
    Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.
    J Leukoc Biol 96:365-375, 2014
  12. Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S & Ogawa H.
    Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.
    PLoS One 9:e94930, 2014
  13. Nishimura N, Gotoh T, Oike Y & Yano M.
    TMEM65 is a mitochondrial inner-membrane protein.
    Peer J 2:e349, 2014

2013年業績

(*Corresponding author)

  1. Kadomatsu T, Uragami S, Akashi M, Tsuchiya Y, Nakajima H, Nakashima Y, Endo M, Miyata K, Terada K, Todo T, Node K & Oike Y*.
    A molecular clock regulates angiopoirtin-like protein 2 expression.
    PLoS One 8:e57921, 2013
  2. Tian Z, Miyata K, Tazume H, Sakaguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M & Oike Y*.
    Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.
    J Mol Cell Cardiol 57:1-12, 2013
  3. Minami T, Jiang S, Schadler K, Suehiro JI, Osawa T, Oike Y, Miura M, Naito M, Kodama T & Ryeom S.
    The calcineurin-NFAT-Angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases.
    Cell Rep 4:709-723, 2013
  4. Akakabe Y, Koide M, Kitamura Y, Matsuo K, Ueyama T, Matoba S, Yamada H, Miyata K, Oike Y & Ikeda K.
    Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.
    Nat Commun 4:2389, 2013
  5. Yano M, Yamamoto T, Nishimura N, Gotoh T, Watanabe K, Ikeda K, Garan Y, Taguchi R, Node K, Okazaki T & Oike Y.
    Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice.
    PLoS One 8:e61380, 2013
  6. Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y & Kiyohara Y.
    Angiopoietin-like protein 2 and risk of type 2 diabetes in a general japanese population: the hisayama study. 
    Diabetes Care 36:98-100, 2013
  7. Toyono T, Usui T, Yokoo S, Kimakura M, Nakagawa S, Yamagami S, Miyata K, Oike Y & Amano S.
    Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation.
    Invest Ophthalmol Vis Sci 54:4278-4285, 2013
  8. Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Höcherl K, Oike Y & Castrop H.
    The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
    Crit Care 17:R130, 2013
  9. Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y & Kiyohara Y.
    Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population.
    Circ J 77:2311-2317, 2013
  10. Yamane K, Jinnin M, Etoh T, Kobayashi Y, Shimozono N, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Aoi J, Oike Y & Ihn H.
    Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK.
    J Mol Med (Berl) 91:69-81, 2013

2012年業績

(*Corresponding author)

  1. Endo M, Kadomatsu T & Oike Y*.
    The roles of angiopoietin-like protein ANGPTL2 in inflammatory carcinogenesis and tumor metastasis.
    Inflamm Regen 32:158-164, 2012
  2. Tazume H, Miyata K, Tian Z, Endo M, Horiguchi H, Takahashi O, Horio E, Tsukano H, Kadomatsu T, Nakashima Y, Kunitomo R, Kaneko Y, Moriyama S, Sakaguchi H, Okamoto K, Hara M, Yoshinaga T, Yoshimura K, Aoki H, Araki K, Hao H, Kawasuji M & Oike Y*.
    Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.
    Arterioscler Thromb Vasc Biol 32:1400-1409, 2012
  3. Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H & Oike Y*.
    Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.
    Cancer Res 72:1784-1794, 2012
    Selected for cover page
  4. Ogata A, Endo M, Aoi J, Takahashi O, Kadomatsu T, Miyata K, Tian Z, Jinnin M, Fukushima S, Ihn H & Oike Y.
    The role of Angiopoietin-like protein 2 in pathogenesis of dermatomyositis.
    Biochem Biophys Res Commun 418:494-499, 2012
  5. Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M & Rakugi H.
    Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.
    Atherosclerosis 220:449-455, 2012
  6. Okazaki H, Hirakawa S, Shudou M, Nakaoka Y, Shirakata Y, Miyata K, Oike Y, Hashimoto K & Sayama K.
    Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B.
    J Dermatol 39:366-374, 2012
  7. Lu M-H, Takemoto M, Watanabe K, Luo H, Nishimura M, Yano M, Tomimoto H, Okazaki T, Oike Y & Song W-J.
    Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice.
    J Physiol 15;590(Pt 16):4029-4044, 2012
  8. Kanda A, Noda K, Oike Y & Ishida S.
    Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye.
    Lab Invest 92:1553-1563, 2012
  9. Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K & Di Noia JM.
    Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1.
    EMBO J 31:679-691, 2012

2011年業績

(*Corresponding author)

  1. Kadomatsu T, Tabata M & Oike Y*.
    Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases.
    FEBS J 278:559-564, 2011
  2. Gotoh T, Endo M & Oike Y.
    Endoplasmic reticulum stress-related inflammation and cardiovascular diseases.
    Int J Inflam. 2011:259462, 2011
  3. Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T, Hirakawa S, Ihn H & Oike Y*.
    Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
    Cancer Res 71:7502-7512, 2011
    Selected for cover page
  4. Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H & Oike Y*.
    C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.
    Arterioscler Thromb Vasc Biol 31:1124-1132, 2011
  5. Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K., Taguchi R, Yamagata K & Oike Y*.
    Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice.
    J Biol Chem 286:3992-4002, 2011
  6. Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y,Nakayama K & Nakayama KI.
    Fbxw7 regulates lipid metabolism and cell fate decision in the mouse liver.
    J Clin Invest 121:342-354, 2011
  7. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K & Kadowaki T.
    Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
    Cell Metab 13:294-307, 2011
  8. Morita M, Oike Y,  Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M & Yamamoto T.
    Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(+/-) mice.
    EMBO J 30:4678-4691, 2011
  9. Muramoto A, Tsushita K, Kato A, Ozaki N, Tabata M, Endo M, Oike Y* & Oiso Y.
    Angiopoietin-like protein 2 sensitively responds to weight reduction induced by lifestyle intervention on overweight Japanese men.
    Nutrition & Diabetes 2011 Nutr Diab 1: e20; doi:10.1038/nutd.2011.16
  10. Tian Z, Miyata K, Tabata M, Yano M, Tazume H, Aoi J, Takahashi O, Araki K, Kawasuji M & Oike Y.
    Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle.
    Hypertens Res 34:1221-1227, 2011
  11. Gotoh T, Endo M & Oike Y.
    Endoplasmic reticulum stress-related inflammation and cardiovascular diseases.
    Int J Inflam 2011:259462, 2011
  12. Takada K, Hirose J, Senba K, Yamabe S, Oike Y, Gotoh T & Mizuta H.
    Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage.
    Int J Exp Pathol 92:232-242, 2011
  13. Shinriki S, Jono H, Ueda M, Ota K, Ota T, Sueyoshi T, Oike Y, Ibusuki M, Hiraki A, Nakayama H, Shinohara M & Ando Y.
    Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma.
    J Pathol 225:142-150, 2011
  14. Adachi H, Kondo T, Koh GY, Nagy A, Oike Y & Araki E.
    Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice.
    Biochem Biophys Res Commun 409:177-180, 2011

2010年業績

(*Corresponding author)

  1. Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H & Oike Y*.
    The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.
    Arterioscler Thromb Vasc Biol 30:1925-1932, 2010
  2. Okada T, Tsukano H, Endo M, Tabata M, Miyata K, Kadomatsu T, Miyashita K, Semba K, Nakamura E, Tsukano M, Mizuta H. & Oike Y*.
    Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis.
    Am J Pathol 176:2309-2319, 2010
  3. Terada K & Oike Y.
    Multiple molecules of Hsc70 and a dimer of DjA1 independently bind to an unfolded protein.
    J Biol Chem 285:16789-16797, 2010
  4. Gotoh T, Endo M & Oike Y
    Endoplasmic reticulum stress-induced transcriptional factor CHOP and cardiovascular diseases.
    Curr Hypertens Rev 6:55-65, 2010
  5. Nakayama Y, Endo M, Tsukano H, Mori M, Oike Y & Gotoh T.
    Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway.
    J Biochem 147:471-483, 2010
  6. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi Y, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K & Kadowaki T.
    Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1.
    Nature 464:1313-1319, 2010
  7. Kurokawa J, Araki S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T & Miyazaki T.
    Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
    Cell Metab 11:479-492, 2010
  8. Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H & Nakayama KI.
    Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.
    J Biol Chem 285:15538-15547, 2010
  9. Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S & Tsubota K.
    Resveratrol prevents light-Induced retinal degeneration via suppressing activator protein-1 activation.
    Am J Pathol 17:1725-1731, 2010
  10. Heishi T, HosakaT, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T, Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H & Sato Y.
    Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenicactivity and suppresses lymph node metastasis.
    Am J Pathol 176:1950-1958, 2010
  11. Ishida S, Koto T, Nagai N & Oike Y.
    Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis.
    Jpn J Ophthalmol 54:594-601, 2010

2009年業績

(*Corresponding author)

  1. Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T & Oike Y*.
    Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation formation and obesity-related systemic insulin resistance.
    Cell Metab 10:178-188, 2009
  2. Oike Y* & Tabata M.
    Angiopoietin-like proteins: potential therapeutic targets for metabolic syndrome and cardiovascular diseases.
    Circ J 73:2192-2197, 2009
  3. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F & Komuro I.
    A crucial role for adipose tissue p53 in the regulation of insulin resistance.
    Nat Med 15:1082-1087, 2009
  4. Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, Araki K, Suda T, Kobatashi K & Oike Y*.
    Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.
    Biochem Biophys Res Commun 381:218-223, 2009
  5. Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y & Araki E.
    Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.
    Biochem Biophys Res Commun 379:806-811, 2009
  6. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota T, Itoh H, Oike Y & Ishida S.
    (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes induced retinal inflammation.
    Diabetes 58:1625-1633, 2009
  7. Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshittake Y, Shinohara M & Ando Y.
    Humanized anti-Interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.
    Clin Cancer Res 15:5426-5434, 2009
  8. Ikeda K, Oike Y, Shimizu T & Taguchi R.
    Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS.
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2639-2647, 2009
  9. Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S & Tsubota K.
    Resveratrol prevents ocular inflammation in endotoxin-induced uveitis via inhibiting oxidative damage and nuclear factor-kB activation.
    Invest Ophthalmol Vis Sci 50:3512-3519, 2009
  10. Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T & Miyazono K.
    Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of Hoxd8 in lymphangiogenesis.
    J Cell Sci 122:3923-3930, 2009
  11. Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y, Izumiya Y, Miyata K, Nakayama K, Kaikita K, Obata T, Takeya M & Ogawa H.
    Activated endocannabinoid system in coronary artery disease and anti-inflammatory effects of cannabinoid 1 receptor blockade on macrophages.
    Circulation 119:28-36, 2009
  12. Namba T, Tanaka K, Ito Y, Ishihara T, Hoshino T, Gotoh T, Endo M, Sato K & Mizushima T.
    Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis.
    Am J Pathol 174:1786-1798, 2009
  13. Debats IB, Wolfs TG, Gotoh T, Cleutjens JP, Peutz-Kootstra CJ & van der Hulst RR.
    Role of arginine in superficial wound healong in man.
    Nitric Oxide 21:175-183, 2009
  14. Villalta SA, Nguyen HX, Deng B, Gotoh T & Tidball JG.
    Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy.
    Hum Mol Genet 18:482-496 2009
  15. Kawahara K, Yoshida A, Koga K, Yokoo S, Kuniyasu A, Gotoh T, Sawada M & Nakayama H.
    Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microglia.
    J. Neuroimmunol 208:70-79, 2009

2008年業績

(*Corresponding author)

  1. Urano T, Ito Y, Akao M, Sawa T, Miyata K, Tabata M, Morisada T, Hato T, Yano M, Kadomatsu T, Yasunaga K, Shibata R, Murohara T, Akaike T, Tanihara H, Suda T & Oike Y*.
    Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
    Arterioscler Thromb Vasc Biol 28:827-834, 2008
  2. Hato T, Tabata M & Oike Y*.
    The role of angiopoietin-like proteins (Angptls) in angiogenesis and metabolism.
    Trends Cardiovasc Med 18:6-14, 2008
  3. Matsuoka S, Oike Y*, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y,
    Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI & Suda T.
    Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
    Genes Dev 22:986-991, 2008
  4. Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H, Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T & Hibi T.
    Hepatic AdiopoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
    Hepatology 48:458-473, 2008
  5. Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota T, Itoh H, Oike Y & Ishida S.
    (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.
    Am J Pathol 173:1911-1918, 2008
  6. Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y & Ishida S.
    Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin.
    Invest Ophthalmol Vis Sci 49:1679-1685, 2008
  7. Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y & Ishida S.
    Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.
    Diabetes 57:2191-2198, 2008
  8. Miyata K, Nakayama M, Mizuta S, Hokimoto S, Sugamura K, Oshima S, Oike Y, Sugiyama S, Ogawa H & Yamamura K.
    Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.
    Biochem Biophys Res Commun 365:207-213, 2008
  9. Suyama K, Ohmuraya M, Hirota M, Ozaki N, Ida S, Endo M, Araki K, Gotoh T, Baba H & Yamamura K.
    C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis.
    Biochem Biophys Res Commun 367:176-182, 2008

欧文総説

2017年

  1. Oike Y*, Tian Z, Miyata K, Morinaga J, Endo M & Kadomatsu T.
    ANGPTL2: a new causal player in accelerating heart disease development in the aging.
    Circ J 81:1379-1385, 2017

2015年

  1. Oike Y*
    Cutting-edge research exploring mechanisms of tissue homeostasis in health and disease.
    Inflamm Regen 35:164-166, 2015
  2. Oike Y*, Kadomatsu T & Endo M.
    The role of ANGPTL2-induced chronic inflammation in lifestyle diseases and cancer.
    Inflamm Regen 35:193-202, 2015

2014年

  1. Kadomatsu T, Endo M, Miyata K & Oike Y*.
    Diverse roles of ANGPTL2 in physiology and pathophysiology.
    Trends Endocrinol Metab 25:245-254, 2014

2012年

  1. Endo M, Kadomatsu T & Oike Y*.
    The roles of angiopoietin-like protein ANGPTL2 in inflammatory carcinogenesis and tumor metastasis.
    Inflamm Regen 32:158-164, 2012

2011年

  1. Kadomatsu T, Tabata M & Oike Y*.
    Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases.
    FEBS J 278:559-564, 2011
  2. Gotoh T, Endo M & Oike Y.
    Endoplasmic reticulum stress-related inflammation and cardiovascular diseases.
    Int J Inflam. 2011:259462, 2011

2010年

  1. Gotoh T, Endo M & Oike Y
    Endoplasmic reticulum stress-induced transcriptional factor CHOP and cardiovascular diseases.
    Curr Hypertens Rev 6:55-65, 2010

2009年

  1. Oike Y* & Tabata M.
    Angiopoietin-like proteins: potential therapeutic targets for metabolic syndrome and cardiovascular disease.
    Circ J 73:2192-2197, 2009

2008年

  1. Hato T, Tabata M & Oike Y*.
    The role of angiopoietin-like proteins (Angptls) in angiogenesis and metabolism.
    Trends Cardiovasc Med 18:6-14, 2008

邦文総説

2018年

  1. 門松 毅、尾池雄一
    メタボリックシンドロームと慢性炎症
    心臓と血管の慢性炎症(生活習慣病)10
    別冊 BIO Clinica 慢性炎症と疾患 7(1):59-63, 2018

2017年

  1. 尾池雄一
    メタボリックシンドローム研究の潮流
    特集:メタボリックシンドローム研究の最前線
    月刊 細胞 THE CELL 49(2):2-3, 2017
  2. 堀口晴紀、尾池雄一
    ANGPTL2による腸管組織修復および恒常性維持制御機構
    日本から発信されたサイエンス No.1
    消化器病学サイエンス 1(1):36-39, 2017
  3. 門松 毅、尾池雄一
    SASP因子としてのアンジオポエチン様因子2と免疫老化
    特集 免疫老化とアンチエイジング 4
    日本抗加齢医学会雑誌 アンチ・エイジング医学 13(3):38-43, 2017

 

学会等発表

2018年

(2018年11月現在)

  1. Tsuyoshi Kadomatsu
    『Roles of angiopoietin-like protein 2 in hematopoietic stem cells』
    (ポスター発表)
    JSPS & NUS 2nd Joint Symposium
    2018年1月19日 熊本市
  2. 尾池雄一
    『心血管疾患と代謝・生活習慣病の共通分子病態におけるANGPTL2の役割』
    (シンポジウム講演)
    第47回日本心脈管作動物質学会
    2018年2月9日 長崎市
  3. 尾池雄一
    『心不全の分子基盤解明と治療戦略』
    (シンポジウム講演)
    第91回日本内分泌学会学術総会
    2018年4月28日 宮崎市
  4. 尾池雄一
    『健康長寿への挑戦』
    (シンポジウム講演)
    熊本大学大学院生命科学研究部附属健康長寿代謝制御研究センター キックオフシンポジウム
    2018年5月2日 熊本市
  5. 尾池雄一
    『ミトコンドリア研究の新展開』
    (シンポジウム4 座長)
    第18回日本抗加齢医学会総会
    2018年5月25日 大阪市
  6. 門松 毅
    『恒常性維持機構の変容による疾患発症の分子基盤~アンジオポエチン様因子2シグナルの観点から~』
    (シンポジウム講演)
    第61回日本糖尿病学会年次学術集会
    2018年5月25日 東京都
  7. 尾池雄一
    『動脈硬化性疾患とアンジオポエチン様因子』
    (シンポジウム講演)
    第50回日本動脈硬化学会総会・学術集会
    2018年7月13日 大阪市
  8. 尾池雄一
    『組織修復に基づく恒常性維持機構の変容による生活習慣病の病態解明と制御』
    (口頭発表)
    AMED-CREST 研究開発領域「生体恒常性維持・変容・破綻機構のネットワーク的理解に基づく最適医療実現のための技術創出」 平成30年度上半期研究開発代表者会合
    2018年7月20日 東京都
  9. 尾池雄一
    『Identification of candidate genes for gene therapy against heart failure』
    (シンポジウム講演)
    第24回日本遺伝子細胞治療学会(JSGCT2018)
    2018年7月28日 東京都
  10. 尾池雄一
    『未来医療の扉を開く医学研究の醍醐味』
    (基調講演)
    熊本大学大学院医学教育部 柴三郎プログラム 夏季セミナー
    2018年8月1日 阿蘇郡
  11. 門松 毅
    『加齢関連疾患の発症・進展とアンジオポエチン様因子2シグナル』
    (シンポジウム講演)
    第91回日本生化学会大会
    2018年9月24日 京都府
  12. 尾池雄一
    『”人生100年時代”に備える健康長寿の極意-サクセスフル・エイジングの秘訣ー』
    (講演)
    熊本県薬剤師会 県民公開講座
    2018年11月11日 熊本市

2017年

  • Tsuyoshi Kadomatsu
    『Role of angiopoietin-like protein 2 as a senescence-associated secretory phenotype(SASP) factor in hematopoietic stem cell maintenance』
    (ポスター発表)
    熊本大学拠点形成A ”International Research Center for Cancer and Metabolism” International Symposium
    2017年2月11日 熊本市
  • Tsuyoshi Kadomatsu
    『Role of angiopoietin-like protein 2 in tumor development and metastasis』
    (口頭発表)
    「新規バイオ医薬ピロール・イミダゾール(PI)ポリアミドの創薬開発国際シンポジウム」平成28年度 日本大学学部連携研究推進シンポジウム
    2017年2月24日 東京都
  • 堀口晴紀
    『腸管組織恒常性維持機構におけるアンジオポエチン様因子2(ANGPTL2)の役割とその変容による発がんの分子機構の解明』
    (口頭発表)
    奥窪医学奨励金受賞講演会
    2017年3月13日 熊本市
  • 田  哲
    『心不全の分子病態解明と治療展開』
    (口頭発表)
    奥窪医学奨励金受賞講演会
    2017年3月13日 熊本市
  • 宮田敬士
    『Endurance Exercise-induced miR221/222 Promotes Cardioprotection via ANGPTL2 Suppression』
    (ポスター発表)
    第81回 日本循環器学会学術集会(JCS2017)
    2017年3月17日 金沢市
  • Zhe Zian
    『ANGPTL2 Activity in Cardiac Pathologies Accelerates Heart Failure by Perturbing Cardiac Function and Energy Metabolism』
    (口頭発表)
    第81回 日本循環器学会学術集会(JCS2017)
    Young Investigator’s Award Basic Research 部門審査講演
    2017年3月17日 金沢市
  • 尾池雄一
    『心血管疾患の分子病態』
    (特別講演)
    第27回 代謝循環フォーラム
    2017年3月21日 東京都
  • 尾池雄一
    『造血幹細胞老化の新規分子基盤解明とその制御』
    (口頭発表)
    セッション2 造血幹細胞とニッチのエイジング
    新学術領域「幹細胞老化と疾患」2017 領域班会議
    2017年6月27日 神戸市
  • 尾池雄一
    『健康長寿に向けた降圧治療』
    (特別講演)
    Session1
    22th Cardiovascular Metabolism and Aging Conference
    2017年7月21日 東京都
  • 宮田敬士
    『ANGPTL2遺伝子を標的とした新規心不全治療薬開発研究
    “ANGPTL2:a novel therapeutic targeting in heart failure”』
    (シンポジウム講演)
    シンポジウム6 心血管領域における遺伝子・細胞治療:最近の進歩 ”Recent Progress on Cardiovascular Gene and Cell Therapy”
    第23回日本遺伝子細胞治療学会学術集会(JSGCT2017)
    2017年7月21日 岡山市
  • 尾池雄一
    『代謝・循環疾患とアンジオポエチン様因子』
    (特別講演)
    第18回Atherosclerosis and Biolipid Conference
    2017年8月5日 京都市
  • 尾池雄一
    『肥満症と心血管疾患の共通分子基盤』
    (シンポジウム講演)
    シンポジウム12 メタボリックシンドロームと心血管病〜新たな分子病態基盤と治療ターゲットの探索〜
    第38回日本肥満学会
    2017年10月8日 大阪市
  • 尾池雄一
    『生活習慣病・がんの共通分子基盤解明〜健康長寿社会実現への挑戦〜』
    (特別講演)
    関西医科大学大学院講座
    2017年10月19日 枚方市
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